Phosphodiesterase (PDE) Inhibitors

PDE1

PDE2

PDE3

PDE4

PDE5

PDE6

PDE7

PDE9

PDE10

PDE11

PDE12

PDE8

Autotaxin

Phosphodiesterase (PDE) Inhibitors, Agonists, Antagonists, Activators, Modulators, Degraders & Substrates

Product Name	PDE1	PDE2	PDE3	PDE4	PDE5	PDE6	PDE7	PDE9	PDE10	PDE11	PDE12	PDE8	Autotaxin	Purity
IBMX			PDE3	PDE4										99.99%
Rolipram				PDE4										99.87%
Roflumilast				PDE4										99.98%
Sildenafil					PDE5									99.99%
PF-06445974 precursor				PDE4B										99.67%
HY-072808				PDE4B										98.75%
Icariin				PDE4, IC₅₀: 73.5 μM	PDE5, IC₅₀: 432 nM									99.06%
Ro 20-1724				PDE4, Ki: 1930 nM										99.98%
Theophylline			PDE3											99.97%
Milrinone			PDE3											99.86%
Apremilast				PDE4, IC₅₀: 74 nM										99.87%
Tadalafil					PDE5									99.95%
Nicotinamide 1,N6-ethenoadenine dinucleotide	PDEI													99.05%
Sildenafil citrate					PDE5									99.86%
Crisaborole				PDE4										99.94%
Cilostamide			PDE3											99.13%
Zatolmilast				PDE4D3, IC₅₀: 7.4 nM PDE4D7, IC₅₀: 7.8 nM										99.50%
ITI-214	PDE1, Ki: 58 pM PDE1A, Ki: 33 pM PDE1B, Ki: 380 pM PDE1C, Ki: 35 pM													99.19%
EHNA hydrochloride		hPDE2A, IC₅₀: 0.8 μM												99.67%
Ziritaxestat													Autotaxin, IC₅₀: 131 nM Autotaxin, Ki: 15 nM	99.93%
Zaprinast					PDE5									99.88%
Bay 60-7550		PDE2												98.39%
Ensifentrine			PDE3, IC₅₀: 0.4 nM	PDE4, IC₅₀: 1479 nM										99.36%
Butein				PDE4, IC₅₀: 10.4 μM										99.64%
PF-8380													Autotaxin, IC₅₀: 2.8 nM (In isolated enzyme assay)	99.05%
FPFT-2216						PDE6D								99.75%
Mardepodect									PDE10A, IC₅₀: 0.37 nM					98.81%
Avanafil	PDE1, IC₅₀: 53000 nM	PDE2, IC₅₀: 51000 nM		PDE4, IC₅₀: 5700 nM	PDE5, IC₅₀: 5.2 nM	PDE6, IC₅₀: 630 nM	PDE7, IC₅₀: 27000 nM		PDE10, IC₅₀: 6200 nM					98.66%
Vardenafil	PDE1, IC₅₀: 180 nM		PDE3, IC₅₀: >1000 nM	PDE4, IC₅₀: >1000 nM	PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM								99.81%
PF-05180999		PDE2A, IC₅₀: 1.6 nM					PDE7B, IC₅₀: 50.09 μM		PDE10A1, IC₅₀: 2.03 μM	PDE11A4, IC₅₀: 26.969 μM				99.96%
BRL-50481							PDE7							99.81%
Moracin M				PDE4D2, IC₅₀: 2.9 μM PDE4B2, IC₅₀: 4.5 μM	PDE5A1, IC₅₀: >40 μM			PDE9A2, IC₅₀: >100 μM						98.99%
D159687				PDE4										98.42%
Balipodect									PDE10					99.47%
TP-10									PDE10					99.95%
(S)-(+)-Rolipram				PDE4, IC₅₀: 1100 nM										99.96%
HA130													Autotaxin, IC₅₀: 28 nM	98.79%
MR-L2				PDE4										98.63%
Difamilast				PDE4B, IC₅₀: 11.2 nM										99.40%
Piclamilast	PDE1, IC₅₀: >100 μM	PDE2, IC₅₀: 40 μM	PDE3, IC₅₀: >100 μM	PDE4, IC₅₀: 16 nM (in pig aorta) PDE4, IC₅₀: 2 nM (in eosinophil soluble)	PDE5, IC₅₀: 14 μM									99.74%
Mirodenafil dihydrochloride					PDE5									99.11%
BAY 2666605			PDE3A, IC₅₀: 87 nM PDE3B, IC₅₀: 50 nM											99.74%
Trequinsin hydrochloride			PDE3											99.86%
PDE4B-IN-2				PDE4B, IC₅₀: 15 nM PDE4D, IC₅₀: 1.7 μM										99.59%
Edelinontrine								PDE9						99.85%
Elpipodect									PDE10A, Ki: 29 pM					98.95%
Vardenafil hydrochloride	PDE1, IC₅₀: 180 nM		PDE3, IC₅₀: >1000 nM	PDE4, IC₅₀: >1000 nM	PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM								99.79%
Fenspiride hydrochloride			PDE3	PDE4	PDE5									99.70%
BRD9500			PDE3A, IC₅₀: 10 nM PDE3B, IC₅₀: 27 nM											98.41%
GSK256066				PDE4, IC₅₀: 3.2 pM										98.69%
ONO-8430506													Autotaxin	99.90%
DNMDP			PDE3											99.46%
Udenafil					PDE5									99.28%
Pimobendan			PDE3											99.82%
Glaucine				PDE4										99.57%
BAY 73-6691								PDE9						99.38%
BI-2545													Autotaxin	98.85%
Cilomilast				LPDE4, IC₅₀: ~100 nM HPDE4, IC₅₀: 120 nM										99.91%
Tribuloside				PDE4, IC₅₀: 6 μM										99.26%
BC11-38									PDE10, IC₅₀: >100 μM	PDE11, IC₅₀: 0.28 μM				99.42%
TMX-4100						PDE6D								98.26%
PF-06445974				PDE4B, IC₅₀: <1 nM PDE4D, IC₅₀: 36 nM PDE4A, IC₅₀: 4.7 nM PDE4C, IC₅₀: 17 nM										98.59%
Tanimilast				PDE4, IC₅₀: 0.026 nM										99.71%
Etazolate hydrochloride				PDE4, IC₅₀: 2 μM										98.00%
PF-05085727		PDE2A, IC₅₀: 2 nM												99.53%
Theophylline (Standard)			PDE3
Sp-cAMPS sodium salt			PDE3A, Ki: 47.6 μM						PDE10 GAF domain, EC₅₀: 50 μM					99.45%
NPD-001	PDE1, IC₅₀: 4 nM	PDE2, IC₅₀: 3 nM												98.11%
DSR-141562	PDE1													99.98%
Naperiglipron									PDE10A1, IC₅₀: 7.43 μM					99.43%
Mirodenafil					PDE5									99.88%
Orismilast				PDE4B3, IC₅₀: 3 nM PDE4D7, IC₅₀: 3 nM PDE4D5, IC₅₀: 3 nM PDE4B2, IC₅₀: 6 nM PDE4D3, IC₅₀: 8 nM PDE4D4, IC₅₀: 8 nM PDE4D1, IC₅₀: 9 nM PDE4D2, IC₅₀: 9 nM PDE4A4, IC₅₀: 11 nM PDE4B1, IC₅₀: 16 nM PDE4A1, IC₅₀: 16 nM PDE4A10, IC₅₀: 52 nM PDE4C2, IC₅₀: 104 nM										99.88%
Sildenafil-d₃					PDE5									99.87%
Oglemilast				PDE4D3, IC₅₀: .5 nM										99.97%
Mardepodect hydrochloride									PDE10					99.94%
PDE12-IN-1											PDE12, pIC₅₀: 9.1			99.11%
Mufemilast				PDE4										99.67%
Enoximone			PDE3/PDE Ⅲ, IC₅₀: 5.9 μM	PDE4A, IC₅₀: 21.1 μM (myocardial PDE4A)										99.91%
PF-04449613								PDE9A, IC₅₀: 22 nM						99.83%
VP3.15 dihydrobromide							PDE7							98.0%
Tetomilast				PDE4										98.15%
Zardaverine			PDE3	PDE4										98.64%
OR-1896			PDE3/PDE Ⅲ											99.04%
Aristolochic acid D		PDE2, IC₅₀: 4.673 μM												99.74%
Nortadalafil					PDE5									99.65%
Icariin (Standard)				PDE4	PDE5
5,7-Dichloropyrazolo[1,5-a]pyrimidine									PDE10A, Ki: 24 μM					99.69%
PF-07038124 hydrochloride				PDE4, : 0.5 nM										99.26%
ML-030				PDE4										99.28%
Olprinone	PDE1, IC₅₀: 150 μM	PDE2, IC₅₀: 100 μM	PDE3, IC₅₀: 0.35 μM	PDE4, IC₅₀: 14 μM										99.58%
Theophylline monohydrate			PDE3											99.93%
KVA-D-88				PDE4B, IC₅₀: 140 nM PDE4D, IC₅₀: 880 nM										99.81%
Lodenafil					PDE5									99.94%
Morcamilast		PDE2A, IC₅₀: 1810 nM	PDE3A, IC₅₀: 2950 nM	PDE4A1, IC₅₀: 1.28 nM PDE4B1, IC₅₀: 2.33 nM PDE4D2, IC₅₀: 1.63 nM					PDE10A2, IC₅₀: 453 nM					98.92%
TyK2-IN-2				PDE4, IC₅₀: 62 nM										99.05%
AGS-16C3F			PDE3											99.81%
TMX-4113						PDE6D								99.08%
PDE5-IN-7	PDE1, IC₅₀: 300 nM				PDE5, IC₅₀: 5 nM									99.83%
Roflupram				PDE4, IC₅₀: 26.2 nM										99.45%
Vardenafil hydrochloride trihydrate	PDE1, IC₅₀: 180 nM		PDE3, IC₅₀: >1000 nM	PDE4, IC₅₀: >1000 nM	PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM								99.67%
SCH 351591				HPDE4, IC₅₀: 58 nM										99.22%
PF-8380 hydrochloride													Autotaxin, IC₅₀: 2.8 nM (In isolated enzyme assay)	99.14%
(Rac)-Apremilast				hPDE4D, IC₅₀: 0.3 nM										99.53%
Irsogladine				PDE4										99.88%
AN3199				PDE4, IC₅₀: 94.5 nM										99.76%
TAK-915	PDE1A, IC₅₀: 2497 nM	PDE2A, IC₅₀: 0.61 nM												99.57%
Autotaxin-IN-3													Autotaxin, IC₅₀: 2.4 nM	98.05%
PAT-505													Autotaxin, IC₅₀: 2 nM (In Hep3B cells) Autotaxin, IC₅₀: 9.7 nM (In human blood ) Autotaxin, IC₅₀: 62 nM (In mouse plasma)	99.47%
Osoresnontrine	PDE1C, IC₅₀: 1 μM PDE1A, IC₅₀: 1.4 μM							PDE9A, IC₅₀: 52 nM						99.94%
Drotaverine hydrochloride				PDE4										99.65%
MY-5445				PDE4, IC₅₀: 37 μM	PDE5, IC₅₀: 6.7 μM PDE5, Ki: 1.3 μM									99.79%
N-Methylbenzamide									PDE10A					99.93%
Robustine					PDE5A									99.70%
PDE7-IN-2							PDE7A, IC₅₀: 2.1 μM							≥99.0%
PF-00489791					PDE5A, IC₅₀: 5 nM									99.70%
PDE5-IN-4					PDE5									99.60%
PDE7-IN-3							PDE7							99.94%
Cudetaxestat													Autotaxin	98.32%
Tofisopam		PDE2A3, IC₅₀: 2.11 μM	PDE3A, IC₅₀: 1.98 μM	PDE4A1, IC₅₀: 0.42 μM					PDE10A1, IC₅₀: 0.92 μM					99.46%
Tovinontrine	PDE1A3, : 88.4 nM PDE1B, : 8.48 nM PDE1C, : 12.2 nM				PDE5A2, : 81.9 nM			PDE9A1, : 8.19 nM PDE9A2, : 9.99 nM						99.83%
TPN171					PDE5, IC₅₀: 0.62 nM									98.10%
PDE12-IN-3											PDE12, pXC₅₀: 7.68			98.02%
Autotaxin modulator 1													Autotaxin	99.40%
GSK356278				PDE4A, pIC₅₀: 8.6 PDE4B, pIC₅₀: 8.8 PDE4D, pIC₅₀: 8.7										99.82%
PDE9-IN-1								PDE9A, IC₅₀: 8.7 nM						99.70%
PDE3B-IN-1			PDE3B, pIC₅₀: 6.5 PDE3A, pIC₅₀: <4.0											99.60%
K134		PDE2	PDE3											99.76%
CI-1044				PDE4A5, IC₅₀: 0.29 μM PDE4B2, IC₅₀: 0.08 μM PDE4C2, IC₅₀: 0.56 μM PDE4D3, IC₅₀: 0.09 μM										98.02%
CD00509	PDEI, IC₅₀: 0.71 μM													98.0%
BAY-7081								PDE9A, IC₅₀: 15 nM						99.03%
Gisadenafil besylate	PDE1A, IC₅₀: 9.1 μM				PDE5A, IC₅₀: 3.6 nM									99.74%
Dovramilast				PDE4										99.66%
CM-675					PDE5, IC₅₀: 114 nM nM									99.53%
Tilivapram				PDE4										99.96%
(S)-C33	PDE1B, IC₅₀: 554 nM	PDE2A, IC₅₀: 2.4 μM		PDE4D2, IC₅₀: 1.3 μM	PDE5A1, IC₅₀: 366 nM			PDE9A, IC₅₀: 11 nM	PDE10A1, IC₅₀: 2.3 μM					99.46%
PDE4-IN-24				PDE4D, IC₅₀: 0.57 nM										99.44%
MBCQ	PDE Ⅰ, IC₅₀: >100 μM	PDE Ⅱ, IC₅₀: >100 μM	PDE Ⅲ, IC₅₀: >100 μM	PDE Ⅳ, IC₅₀: >100 μM	PDE V, IC₅₀: 19 nM									99.80%
Olprinone Hydrochloride			PDE3											99.85%
THPP-1									PDE10					98.75%
Carbodenafil					PDE5									99.63%
Sp-cAMPS			PDE3A, Ki: 47.6 μM						PDE10 GAF domain, EC₅₀: 50 μM
PDE1-IN-9	PDE1C, IC₅₀: 11 nM
Acetildenafil					PDE5									99.0%
PQ-10									PDE10A, IC₅₀: 4.6 nM					99.77%
Sophoflavescenol					PDE5									98.78%
Hcyb1		PDE2												98.20%
PDE1-IN-2	PDE1A, IC₅₀: 164 nM PDE1B, IC₅₀: 140 nM PDE1C, IC₅₀: 6 nM													98.0%
EMD 53998			PDE3											99.59%
Mesopram				PDE4										98.80%
S32826 disodium													Autotaxin, IC₅₀: 8.8 nM	98.85%
PDE1-IN-9 hydrochloride	PDE1C, IC₅₀: 11 nM
PDE4B-IN-3				PDE4B, IC₅₀: .94 μM										99.37%
PBF-999									PDE10A					98.89%
K-Ras-PDEδ-IN-1				PDE4, Kd: 8.3 nM										99.45%
PDE10A-IN-2 hydrochloride									PDE10A, IC₅₀: 2.8 nM					98.43%
LEO 39652				PDE4D, IC₅₀: 3.8 nM PDE4A, IC₅₀: 1.2 nM PDE4B, IC₅₀: 1.2 nM PDE4C2, IC₅₀: 3.0 nM										99.51%
ATX inhibitor 5													Autotaxin	99.20%
ent-Tadalafil					PDE5, IC₅₀: 10 μM									98.17%
Lirimilast				PDE4, IC₅₀: 42 nM										98.69%
PDE2A-IN-3		PDE2A, IC₅₀: 69 nM							PDE10, IC₅₀: 1762 nM					99.88%
FCPR03				PDE4 catalytic domain, IC₅₀: 60 nM PDE4B1, IC₅₀: 31 nM PDE4D7, IC₅₀: 47 nM										99.82%
FR-229934					PDE V									99.66%
BIO-32546													Autotaxin	99.05%
RS-25344 hydrochloride	PDE Ⅰ, IC₅₀: >100 μM	PDE Ⅱ, IC₅₀: 160 μM	PDE Ⅲ, IC₅₀: 330 μM	PDE Ⅳ, IC₅₀: 0.28 nM										99.93%
Atizoram				PDE4
BW-A 78U				PDE4, IC₅₀: 3 μM										99.67%
Motapizone			PDE3
PDE4-IN-4				PDE4
PDE7A-IN-1				PDE4D, IC₅₀: 1.6 μM			PDE7A, IC₅₀: 3.7 nM PDE7B, IC₅₀: 0.2 μM							99.83%
GS-5759				PDE4										99.21%
Kuraridine					PDE5, IC₅₀: 0.64 μM									98.0%
MK-0873				PDE4
Lodenafil carbonate					PDE5									98.0%
MK-0952				PDE4, IC₅₀: 0.53 nM										99.71%
Yonkenafil hydrochloride					PDE5									99.43%
Ayanin		PDE2A		PDE4										98.18%
Thioquinapiperifil dihydrochloride	PDE1, IC₅₀: 380 nM	PDE2, IC₅₀: 670 nM	PDE3, IC₅₀: 38 nM	PDE4, IC₅₀: 800 nM	PDE5, IC₅₀: 0.074 nM									99.22%
Autotaxin-IN-6													Autotaxin, IC₅₀: 30 nM	99.88%
ATX inhibitor 11													Autotaxin, IC₅₀: 2.7 ± 1 nM	99.44%
Apremilast-d₅				PDE4										99.26%
PDE10-IN-1									PDE10					99.44%
T-0156	PDE1, IC₅₀: >100 μM	PDE2, IC₅₀: >100 μM	PDE3, IC₅₀: >100 μM	PDE4, IC₅₀: 63 μM	PDE5, IC₅₀: 0.23 nM	PDE6, IC₅₀: 56 nM
CDC801				PDE4										98.94%
ITI-214 free base	PDE1, Ki: 58 pM PDE1A, Ki: 33 pM PDE1B, Ki: 380 pM PDE1C, Ki: 35 pM													98.0%
Mesembrine				PDE4B, IC₅₀: 7.8 μM
PDM-631		PDE2A, IC₅₀: 1.5 nM (human) PDE2A, IC₅₀: 4.2 nM (rat)
PF-07038124				PDE4B2, IC₅₀: 0.5 nM
LASSBio-1632				PDE4A PDE4D
PF-04822163	PDE1A, IC₅₀: 2 nM PDE1B, IC₅₀: 2.4 nM PDE1C, IC₅₀: 7 nM	PDE2A, IC₅₀: 5895 nM	PDE3A, IC₅₀: >30000 nM	PDE4D3, IC₅₀: 7620 nM	PDE5A1, IC₅₀: >30000 nM		PDE7B, IC₅₀: >29800 nM	PDE9A1, IC₅₀: >30000 nM	PDE10A1, IC₅₀: 252 nM	PDE11A4, IC₅₀: 8257 nM
Vardenafil dihydrochloride	PDE1, IC₅₀: 180 nM				PDE5, IC₅₀: 0.7 nM	PDE6, IC₅₀: 11 nM
Avanafil dibenzenesulfonate	PDE1, IC₅₀: 53000 nM	PDE2, IC₅₀: 51000 nM		PDE4, IC₅₀: 5700 nM	PDE5, IC₅₀: 5.2 nM	PDE6, IC₅₀: 630 nM	PDE7, IC₅₀: 27000 nM		PDE10, IC₅₀: 6200 nM
TPN729MA	PDE1, IC₅₀: 566 nM			PDE4, IC₅₀: 834 nM	PDE5, IC₅₀: 2.28 nM	PDE6, IC₅₀: 45.2 nM				PDE11, IC₅₀: 6090 nM				99.45%
TPN729	PDE1, IC₅₀: 566 nM			PDE4, IC₅₀: 834 nM	PDE5, IC₅₀: 2.28 nM	PDE6, IC₅₀: 45.2 nM				PDE11, IC₅₀: 6090 nM
Autotaxin-IN-4													Autotaxin
PDE5-IN-2		PDE2A, IC₅₀: 106 nM		PDE4D2, IC₅₀: 43 nM	PDE5A1, IC₅₀: 0.31 nM	PDE6C, IC₅₀: 1.2 nM			PDE10A, IC₅₀: 46 nM
Indimilast				PDE4
MT-3014									human PDE 10A, IC₅₀: 0.062 nM bovine PDE 10A, IC₅₀: 0.09 nM
PDE4-IN-28				PDE4D, IC₅₀: 29 nM
Autotaxin-IN-8													Autotaxin, IC₅₀: 14.2 nM
WIN-63291			PDE Ⅲ
ID11916					PDE5
Sp-cAMPS triethylamine			PDE3A, Ki: 47.6 μM						PDE10 GAF domain, EC₅₀: 50 μM
PDE10A-IN-5									PDE10A, IC₅₀: 3.5 nM
PDE4-IN-30				PDE4D2, IC₅₀: 2.7 nM	PDE5A, IC₅₀: 7491 nM				PDE10A, IC₅₀: 181.8 nM			PDE8A, IC₅₀: 1156 nM
Revamilast				PDE4, IC₅₀: 3 nM
Menabitan dihydrochloride								PDE9
Trequinsin			PDE3, IC₅₀: <1 nM
PDE11A4-IN-2										PDE11A4, IC₅₀: 33 nM
OPC 33540	PDEI, IC₅₀: 42.9 μM	PDE2, IC₅₀: 52.3 μM	PDE3A, IC₅₀: 0.32 nM PDE3B, IC₅₀: 1.5 nM	PDE4, IC₅₀: 100.8 μM	PDE5, IC₅₀: 2.5 μM		PDE7, IC₅₀: 51.3 μM
P7–2302				PDE4B, IC₅₀: 77.3 nM			PDE7, IC₅₀: 0.18 nM
Gemlapodect									PDE10A
PDE11-IN-1										PDE11				98.23%
PDEδ/NAMPT IN-1						PDE6, Kd: 0.41 nM
PDE4-IN-6				PDE4B, IC₅₀: 0.125 μM PDE4D, IC₅₀: 0.43 μM
PDE4-IN-15				PDE4
KRAS IN-44						PDE6D
Meribendan			PDE Ⅲ
Thioquinapiperifil	PDE1, IC₅₀: 380 nM	PDE2, IC₅₀: 670 nM	PDE3, IC₅₀: 38 nM	PDE4, IC₅₀: 800 nM	PDE5, IC₅₀: 0.074 nM
Theophylline L-lysine			PDE3
Deltazinone 1						PDEδ, Kd: 8 nM								98.79%
(1R,2R)-Elpipodect									PDE10A, Ki: 29 pM
PDE4-IN-34				PDE4B1, IC₅₀: 19 pM PDE4D2, IC₅₀: 14 pM								PDE8A1, IC₅₀: 4.092 μM
PDE11A4-IN-1										PDE11A4, IC₅₀: 12 nM
PDE3/4-IN-3			PDE3A, IC₅₀: 0.17 nM	PDE4B2, IC₅₀: ≤50 nM
S32826													Autotaxin, IC₅₀: 8.8 nM
T-1032 free base					PDE5, IC₅₀: 1.0 nM
PDE5-IN-3					PDE5, IC₅₀: 1.57 nM
Imazodan hydrochloride			PDE3/PDE Ⅲ
PDE2A-IN-2		PDE2A, Ki: 5.49 nM
EL244													Autotaxin, IC₅₀: 50 nM	99.55%
PDE5-IN-13	PDE1C, IC₅₀: 10478 nM	PDE2A, IC₅₀: 3378 nM	PDE3A, IC₅₀: >100000 nM	PDE4D2, IC₅₀: 53294 nM	PDE5A, IC₅₀: 3 nM	PDE6C, IC₅₀: 20 nM	PDE7A, IC₅₀: 25746 nM	PDE9A2, IC₅₀: >100000 nM	PDE10A2, IC₅₀: 21160 nM	PDE11A, IC₅₀: >100000 nM		PDE8A1, IC₅₀: >100000 nM
PROTAC PDE4 degrader-1				PDE4, DC₅₀: 41.98 μM
(R)-Xanthoanthrafil					PDE5
Z21090				PDE4, IC₅₀: 37.4 nM
LT-104A				PDE4D3, IC₅₀: 9.3 μM
Menabitan								PDE9
BMS-341400					PDE5, IC₅₀: 0.3 nM
CK-2289			PDE Ⅲ
PF-03049423 free base					PDE5A
ATX inhibitor 18													Autotaxin, IC₅₀: 24.2 nM
PDE4B-IN-6				PDE4B, IC₅₀: 7.42 nM PDE4A, IC₅₀: 1540 nM PDE4C, IC₅₀: 1260 nM
PDE4-IN-12				PDE4D2, IC₅₀: 3.51 nM PDE4B2, IC₅₀: 9.51 nM	PDE5A1, IC₅₀: 1.24 μM		PDE7A, IC₅₀: 15 nM		PDE10A, IC₅₀: 1.02 μM			PDE8A1, IC₅₀: 194 nM
MDL 19205			PDE3
Multitarget AD-IN-6	PDE1B, IC₅₀: 54.47 μM	PDE2A, IC₅₀: 79.61 μM	PDE3A, IC₅₀: 8.39 μM	PDE4B, IC₅₀: 15.54 μM hPDE4D, IC₅₀: 130.50 μM	PDE5A, IC₅₀: 26.86 μM		PDE7A, IC₅₀: 15.15 μM		human PDE 10A, IC₅₀: 36.13 μM			PDE8A, IC₅₀: 16.46 μM
CM-545					PDE5, pIC₅₀: 7.47
Gisadenafil	PDE1A, IC₅₀: 9.1 μM				PDE5A, IC₅₀: 3.6 nM
(R)-Irsenontrine								PDE9, IC₅₀: 0.041 μM						99.00%
PDE5-IN-9					PDE5									98.0%
PDE4B-IN-4				PDE4B, IC₅₀: 2.82 nM
PDE4-IN-29				PDE4A1 PDE4B2 PDE4D3
ASP9436									human PDE 10A, IC₅₀: 8 nM
Tofimilast				PDE4, IC₅₀: 0.14 μM
ATX inhibitor 20													Autotaxin, IC₅₀: 2.3 ± 0.31 nM
PDE2-IN-1		PDE2, IC₅₀: 0.6 μM
AN-2898	PDE1A, IC₅₀: 1.7 μM	PDE2A, IC₅₀: 9.8 μM	PDE3A, IC₅₀: 4.12 μM	PDE4, IC₅₀: 0.027 μM PDE4B1, IC₅₀: 0.24 μM PDE4A1, IC₅₀: 0.35 μM PDE4D2, IC₅₀: 0.84 μM			PDE7A, IC₅₀: 0.21 μM
ATX inhibitor 15													Autotaxin, IC₅₀: 2.17 nM
PDE5/HDAC-IN-1					PDE5, IC₅₀: 46.3 nM
Norbraylin				PDE4D2, IC₅₀: 7.15 μM
T-1032					PDE5, IC₅₀: 1.0 nM
PDE/TRPA1/CHIT1-IN-1	PDE1B, IC₅₀: 54.47 μM	PDE2A, IC₅₀: 79.61 μM	PDE3A, IC₅₀: 8.39 μM	PDE4B, IC₅₀: 15.54 μM PDE4D, IC₅₀: 130.50 μM	PDE5A, IC₅₀: 26.86 μM		PDE7A, IC₅₀: 15.15 μM		PDE10A, IC₅₀: 36.13 μM			PDE8A, IC₅₀: 16.64 μM
PDE4-IN-18				PDE4, IC₅₀: 1.55 μM
PDE4-IN-33				PDE4
ORG-20241			PDE3	PDE4
ATX inhibitor 12													Autotaxin, IC₅₀: 1.72 nM
PDE4-IN-26				PDE4A, IC₅₀: 89.7 nM PDE4B, IC₅₀: 48.8 nM PDE4D, IC₅₀: 5.9 nM
PDE10A-IN-1									PDE10A, IC₅₀: 250 nM
Anagrelide hydrochloride monohydrate			PDE3
ICI-63197	PDE Ⅰ, Ki: 487 μM	PDE Ⅱ, Ki: >1000 μM	PDE3/PDE Ⅲ, Ki: 9 μM	PDE Ⅳ, Ki: 10 μM										99.14%
BJH-86									PDE10A
GPR61 Inverse agonist 3			PDE3A, : 8.9 μM
PDE4B/D-IN-4				PDE4B, IC₅₀: 5.50 nM PDE4D, IC₅₀: 6.81 nM
Etazolate				PDE4
CPL500036									PDE10A, IC₅₀: 1 nM PDE10A, IC₅₀: 35 nM
PDE4-IN-11				PDE4
LY2775240				PDE4A, IC₅₀: 0.09 nM PDE4B, IC₅₀: 0.09<br/> nM PDE4D, IC₅₀: 0.14 nM PDE4C, IC₅₀: 2.4 nM
Phosphodiesterase-IN-2									PDE10A, IC₅₀: 11.9 nM
ATX inhibitor 19													Autotaxin, IC₅₀: 156 ± 19.8 nM
D159153				PDE4
PDE5-IN-14					PDE5, IC₅₀: 16.11 nM
ATX inhibitor 14													Autotaxin, IC₅₀: 0.41 nM
PDE2A-IN-1		PDE2
Arofylline				PDE4
Ilexsaponin B2	PDEI, IC₅₀: 477.5 μM				PDE5, IC₅₀: 48.8 μM
Autotaxin-IN-1													Autotaxin, IC₅₀: 2 nM
Phosphodiesterase-IN-5									PDE10A, IC₅₀: 6.2 nM
ATX inhibitor 8													Autotaxin
BC8-15				PDE4A, IC₅₀: 0.22 μM			PDE7A, IC₅₀: 6.46 μM					PDE8A, IC₅₀: 0.28 μM
GRI918013													Autotaxin
CM-414					PDE5, IC₅₀: 60 nM
BrP-LPA sodium													Autotaxin
ASP9831				PDE4
PF-04677490	PDE1B, IC₅₀: 21 nM PDE1C, IC₅₀: 83 nM PDE1A, IC₅₀: 118 nM
Z19153				PDE4B1, IC₅₀: 110 nM PDE4D7, IC₅₀: 1160 nM
PDE5-IN-10					PDE5, IC₅₀: 20 nM
JNJ-42314415									human PDE 10A, Ki: 35 nM
LH17	PDE1B2, IC₅₀: >10000 nM	PDE2A, IC₅₀: >10000 nM	PDE3A, IC₅₀: >10000 nM	PDE4D2, IC₅₀: 73 nM PDE4B2, IC₅₀: 190 nM	PDE5A1, IC₅₀: >10000 nM		PDE7A1, IC₅₀: 300 nM PDE7A1, IC₅₀: >10000 nM	PDE9A1, IC₅₀: >10000 nM	PDE10A1, IC₅₀: >10000 nM			PDE8A1, IC₅₀: >10000 nM
1,3,5-Trihydroxy-4-prenylxanthone					PDE5, IC₅₀: 3 μM
FR-181074					PDE V
PDE4-IN-32				PDE4B, IC₅₀: 13.7 nM PDE4D, IC₅₀: 23.8 nM
NVP-ABE171				PDE4D, IC₅₀: 1.5 nM PDE4B, IC₅₀: 34 nM PDE4A, IC₅₀: 602 nM PDE4C, IC₅₀: 1230 nM
PDE4B-IN-5				PDE4B2, IC₅₀: <10 nM
PDE1-IN-12	PDE1
ATX inhibitor 26													Autotaxin, IC₅₀: 57 nM
Neuroprotective agent 12				PDE4B
12-epi-Tadalafil					PDE5, IC₅₀: 0.09 μM
THPP-2									PDE10A, Ki: 94 nM
PDE1-IN-7	PDEI, IC₅₀: 10 nM
PDE5-IN-15	PDE1		PDE3		PDE5	PDE6
TM-04-064-02						PDE6D
KD-027					PDE5
CDP-840				PDE4
Autotaxin-IN-5													Autotaxin
S-Petasin			PDE3, IC₅₀: 25.5 μM PDE3, Ki: 25.3 μM	PDE4, IC₅₀: 17.5 μM PDE4, Ki: 18.1 μM
Lixazinone hydrogensulfate			PDE3, IC₅₀: 22 μM
Fenspiride			PDE3	PDE4	PDE5
PDE4D inhibitor 1	PDE1B2, IC₅₀: >10000 nM	PDE2A, IC₅₀: >10000 nM	PDE3A, IC₅₀: >10000 nM	PDE4B1, IC₅₀: 5.3 nM PDE4D2, IC₅₀: 8.6 nM PDE4A10, IC₅₀: 100 nM PDE4C1, IC₅₀: 747 nM	PDE5A1, IC₅₀: 1730 nM		PDE7A1, IC₅₀: 5913 nM	PDE9A2, IC₅₀: >10000 nM	PDE10A2, IC₅₀: 1953 nM			PDE8A1, IC₅₀: >10000 nM
PDE4-IN-5				PDE4
JNJ-42396302									PDE10A
Mesembranol				PDE4
PDE4B/D-IN-5				PDE4B1, IC₅₀: 3.4 nM PDE4D3, IC₅₀: 2.2 nM
GSK4394835A			PDE3B, pIC₅₀: 6.2
MHC00188													Autotaxin
PDE1-IN-10	PDE1, IC₅₀: 5 nM
KW-4490				PDE4
PDE4-IN-8				PDE4B2, IC₅₀: 0.93 nM
Avanafil-¹³C,d₃	PDE1
Lixazinone			PDE3, IC₅₀: 22 nM
Deacetylsclerotiorin				PDE4, IC₅₀: 2.8 μM
Theophylline sodium acetate			PDE3
PDE4-IN-13				PDE4, IC₅₀: 1.56 μM
Talaroterphenyl A				PDE4, IC₅₀: 1.2 μM
PDE3/4-IN-2			PDE3A, IC₅₀: 0.13 nM	PDE4B1, IC₅₀: 50 nM
PDE3/4-IN-4	PDE1A, IC₅₀: >10000 nM	PDE2A, IC₅₀: >10000 nM	PDE3A, IC₅₀: 10 nM	PDE4B, IC₅₀: 9.4 nM	PDE5A, IC₅₀: >10000 nM	PDE6C, IC₅₀: 5739 nM	PDE7A, IC₅₀: >10000 nM		PDE10A, IC₅₀: 477.9 nM	PDE11A, IC₅₀: >10000 nM		PDE8A, IC₅₀: >10000 nM
TC-E 5005		PDE2A, IC₅₀: 239 nM	PDE3A, IC₅₀: 3700 nM		PDE5A, IC₅₀: 919 nM		PDE7B, IC₅₀: 3100 nM		PDE10A, IC₅₀: 7.28 nM	hPDE11A, IC₅₀: 779 nM
PDE4B/7A-IN-1				PDE4B, IC₅₀: 69 μM			PDE7A, IC₅₀: 57 μM
AChE/PDE4-IN-1				PDE4, IC₅₀: 1.88 μM
PDE4B-IN-7				PDE4B, IC₅₀: 160 nM
PDE4B/7A-IN-2				PDE4			PDE7
PDE5-IN-5					PDE5, IC₅₀: 2.0 nM
ATX inhibitor 21													Autotaxin, IC₅₀: 3490 ± 170 nM
Tofisopam (Standard)		PDE2A3, IC₅₀: 2.11 μM	PDE3A, IC₅₀: 1.98 μM	PDE4A1, IC₅₀: 0.42 μM					PDE10A1, IC₅₀: 0.92 μM
Catramilast				PDE4D
Z21115				PDE4D7, IC₅₀: 10.5 nM PDE4D, IC₅₀: 65.7 nM PDE4B, IC₅₀: 64.4 nM
L-869298				PDE4A, IC₅₀: 0.5 nM
PyP-1									PDE10A2, Ki: 0.32 nM
PDE5-IN-12					PDE5, IC₅₀: 22 nM
PF-03049423					PDE5A
PDE4/5-IN-1				PDE4B2 PDE4D2	PDE5	PDE6				PDE11
V11294				hPDE4D, Ki: 436 nM
PDE1-IN-4	PDE1C, IC₅₀: 10 ± 3 nM PDE1A, IC₅₀: 145 nM PDE1B, IC₅₀: 354 nM	PDE2A, IC₅₀: 5130 nM	PDE3A, IC₅₀: >10000 nM	PDE4B2, IC₅₀: 619 nM PDE4D2, IC₅₀: 948 nM	PDE5A1, IC₅₀: 1810 nM			PDE9A2, IC₅₀: >10000 nM	PDE10A, IC₅₀: 1310 nM
BC-54				PDE4			PDE7
PDE4-IN-19				PDE4B1, IC₅₀: <10 nM PDE4D3, IC₅₀: 10-100 nM
PDE4-IN-10				PDE4B, IC₅₀: 7.01 ± 1.0 μM
P7-2104							PDE7A, IC₅₀: 31 nM							99.77%
PDE1-IN-8	PDE1C, IC₅₀: 11 nM PDE1A, IC₅₀: 263 nM PDE1B, IC₅₀: 357 nM	PDE2A, IC₅₀: 1820 nM	PDE3A, IC₅₀: 5164 nM	PDE4D, IC₅₀: 3006 nM	PDE5A, IC₅₀: 681 nM		PDE7A, IC₅₀: 2093 nM	PDE9A, IC₅₀: 4617 nM	PDE10A, IC₅₀: 2394 nM			PDE8A, IC₅₀: 3729 nM
Ensifentrine tosylate			PDE3, IC₅₀: 0.4 nM	PDE4, IC₅₀: 1479 nM
MS 857			PDE3
Pumafentrine			PDE3	PDE4
PF-04827736	PDE1B, IC₅₀: 9.1 nM PDE1A, IC₅₀: 42 nM PDE1C, IC₅₀: 38 nM
Ronomilast				PDE4, IC₅₀: 3 nM
SAR156497			PDE3, IC₅₀: 4 μM
PDE1-IN-11	PDE1A													99.24%
BL-122					PDE5
UK 343664					PDE5
ATX inhibitor 22													Autotaxin, IC₅₀: 218 nM
CP-220629				PDE4, IC₅₀: 0.44 μM
AMG580									PDE10A
CC-3052				PDE4
UK-500001				PDE4D3, IC₅₀: 0.28 nM PDE4B2, IC₅₀: 22.8 nM PDE4A4, IC₅₀: 26.1 nM PDE4C2, IC₅₀: 217 nM
MEY-003													Autotaxin
N-Desethyl-N-methyl vardenafil					PDE5, IC₅₀: 0.14 μM
Xanthoanthrafil					PDE5, : 3.95 ng/mL
SCH 51866	PDE1, IC₅₀: 70 nM				PDE5, IC₅₀: 60 nM
AWD 12-281				PDE4, IC₅₀: 9.7 nM
Pelrinone			PDE Ⅲ, IC₅₀: 36 μM
RS14203				PDE4
BML-288		PDE2, IC₅₀: 40 nM
UK-371800					PDE5
UK 357903					PDE5, IC₅₀: 1.7 nM	PDE6, IC₅₀: 714 nM
PDE4-IN-25				PDE4, IC₅₀: 0.1 μM
LEO 29102				PDE4, IC₅₀: 5 nM
Irsogladine maleate				PDE4										98%
PDE4-IN precursor				PDE4
PF-06815189		PDE2A, IC₅₀: 0.4 nM
Mardepodect precursor									PDE10A, IC₅₀: 0.37 nM
P2Y12/PDE5-IN-1					PDE5, : 0.154 μg/mL
KF-17625				PDE4, IC₅₀: 12 μM
Sudachitin	PDE1C, IC₅₀: 5 μM			PDE4B, IC₅₀: 15 μM
ONO-6126				PDE4
JNJ-10258859	PDE1, Ki: >100 μM	PDE2, Ki: 25.33±5.53 μM	PDE3, Ki: 9.67±1.95 μM	PDE4, Ki: 5.01±1.88 μM	PDE5, Ki: 0.23±0.03 nM
MMPX	PDEI
BMS-341400 mesylate					PDE5, IC₅₀: 0.3 nM
L791943				PDE4

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